ABSTRACT
Objective To investigate the effect of constraint abstinence duration on regional homogeneity (ReHo) of heroin addicts in resting state.Methods Twenty heroin addicts abstinent for 6 months (PA6 group),sixteen heroin addicts abstinent for 11 months (PA11 group) and 30 demographically matched healthy controls (HC group) were enrolled.ReHo values were calculated and difference among three groups was analyzed.The relationship between ReHo values of differential brain regions and abstinent duration was performed with Pearson method.Results The results demonstrated statistically significant difference in ReHo values among three groups in the left parahippocampal gyrus,caudate,insula,cingulate gyrus,postcentral gyrus and right orbitofrontal cortex.Compared with the PA6 group,the PA11 group demonstrated lower ReHo value in left parahippocampal gyrus,caudate,insula,cingulate gyrus and postcentral gyrus,ReHos value were higher than PA6 and HC in right orbitofrontal cortex.Meanwhile,the ReHo values of left parahippocampal gyrus (r=0.53,P=0.000 8),caudate (r=0.54,P=0.000 6),insula (r=0.62,P＜0.000 1),cingulate gyrus (r=0.47,P=0.003 5) and postcentral gyrus (r=0.35,P 0.034 8) were negatively correlated with abstinence duration and ReHo value of right orbitofrontal cortex (r=0.66,P＜0.000 1) were positively correlated with abstinence duration.Conclusion During long-term abstinence,most of heroin addicts' damaged brain regions (mainly involved in craving,inhibitory control,learning and memory) tends to be normal,thus benefit reducing the risk of relapse,but motivation related brain region's (orbitofrontal cortex) neural activity increases abnormally,that may be one of the important reasons for relapse after abstinence.
ABSTRACT
Objective To explore the value of the spiral CT three-dimensional reconstruction imaging in congenital dislocationof hip(CDH) in children.Methods A total of 45 patients(59 hips) with CDH were checked-up with spiral CT and three-dimensionalreconstruction imaging before operation.The femoral neck anteversion(FNA) and the acetabular index(AI) were measured and alsocompared with the seeing in operation.Results The patients' FNA were all greater than normal,with the greatest was 90?and the smaller was 40?,the average was 42.72??12.06?.Their AI were also greater,with the average of 35.4??9.5?,the acetabulum were hypogenesis with different degreee.Conclusion The 3D CT of hip joint provides precise information of the imaging compare with the X-ray.It is a very useful technique in the FNA and AI measuring and it is also useful for the diagnosis and treatment planning of CDH.